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US awards Moderna $176m for bird flu vaccine development | The Express Tribune

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LOS ANGELES:

The US government on Wednesday announced $176 million in investment in biotech company Moderna to develop a vaccine against bird flu as concerns escalate over a multi-state outbreak in dairy cows.

This initiative comes as the ongoing outbreak of influenza A (H5N1), commonly known as bird flu, has infected at least 132 dairy cow herds across 12 states, with three confirmed human cases linked to exposure to sick cows, since the virus was, for the first time, detected in cows on March 25, according to the latest data from the Centers for Disease Control and Prevention (CDC) on June 28.

The investment, to be channeled through the Biomedical Advanced Research and Development Authority (BARDA), will empower Moderna to leverage its mRNA technology, which was used in their COVID-19 vaccine, to develop a pandemic influenza vaccine, according to the news release of the US Department of Health and Human Services (HHS) on Tuesday.

Moderna’s COVID vaccine is one of the first two vaccines authorized by the US Food and Drug Administration (FDA) during the COVID-19 response, and ultimately licensed by the FDA, said the release.

The funding will support the preparation of materials, clinical trials to assess safety and immune response, and ultimately, the pursuit of FDA approval. It will also help ensure the vaccine’s readiness for large-scale production in the event of a public health emergency, according to the HHS.

The award has been met with positive reactions from public health experts, including Rick Bright, former BARDA director, who described it as a “big step forward” in modernizing pandemic response capabilities.

“New, synthetic vaccines can be tailored to induce broader immunity than to a single strain of influenza and can be made at large volumes, much faster, without added adjuvant,” Bright wrote on social media X following the HHS’s announcement Tuesday.

However, he also expressed concerns about the adequacy of testing and transparency in the ongoing H5N1 outbreak.

With few people tested for antibodies to H5N1, it’s difficult to track mild or asymptomatic infection, human-to-human spread, or even individuals with confirmed infections, he said in an earlier post on X. “More progress needed with serology testing,” he said.

Additionally, Bright criticised the US Department of Agriculture (USDA) for not being transparent about the outbreak’s size and scope, noting that the number of cows in infected herds is often not disclosed, making it difficult to assess the full extent of the outbreak.

When more than 100 herds were reported to be infected, this could mean “tens to hundreds of thousands of infected cows overall,” he said.

With six dairy cow herds confirmed to be infected over the past week, Colorado has emerged as a particular hotspot, according to data from the USDA and the State Department of Agriculture.

The state has seen 26 herds reported to have bird flu cases this year, most of which occurred in the past month, representing nearly a quarter of the state’s herds, the data shows.

Despite the growing number of infected herds, only 53 people have been tested for the virus to date, according to the CDC. In May, the USDA allocated funding for the dairy herd status program, which requires voluntary weekly testing.

However, only six herds have enrolled thus far, according to the USDA’s website.

Although the CDC states that the current threat to humans is very low, experts are increasingly concerned that the longer the virus spreads unchecked among animals, the higher the likelihood that it will mutate into a form more dangerous to people.

“Humans have no natural immunity to the virus,” warned Christer Watson, a science writer, in an article posted on the Journal Gazette’s website on Tuesday. “As viruses mutate and evolve… the fear is that a virus could mutate so that it is able to attach to the surface of cells in the human upper respiratory tract,” he wrote.

He is worried that “every time a human is infected with H5N1 from a cow, it is a roll of the dice whether that virus has the dangerous respiratory mutation.”

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SpaceX achieves unprecedented feat in commercial space travel | The Express Tribune

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WASHINGTON:

Two astronauts, a billionaire and an engineer, completed the first private spacewalk in orbit on Thursday outside a SpaceX capsule. They wore a new type of spacesuit in a high-risk feat once limited to astronauts from government space agencies.

As part of the Polaris Dawn mission, the astronauts each spent about 10 minutes outside the Crew Dragon capsule, tethered for safety, while their two crewmates remained inside. The mission, led by Elon Musk’s SpaceX, further pushed the boundaries of private space travel.

Jared Isaacman, a pilot and founder of Shift4, was the first to exit, followed by SpaceX engineer Sarah Gillis. Meanwhile, their crewmates Scott Poteet and Anna Menon observed from inside the capsule. Orbiting about 450 miles (730 km) above Earth, the entire spacewalk lasted one hour and 46 minutes.

Isaacman, who also funded the Polaris mission, previously financed his Inspiration4 flight with SpaceX in 2021. The mission, streamed live on SpaceX’s website, tested new equipment, including slimmer spacesuits and a procedure to fully depressurise the Crew Dragon cabin – technology that Musk aims to refine for future private missions to Mars.

After re-entering the spacecraft, Isaacman commented on Earth’s beauty, as seen from space. This mission was one of the riskiest for SpaceX, the only private company capable of regularly sending people into orbit and back.

Before the spacewalk at around 10:52 GMT, the capsule was completely depressurised, with the astronauts relying on their SpaceX-designed spacesuits for oxygen via an umbilical connection to the capsule. Isaacman, 41, and Gillis, 30, tested the suits’ flexibility and provided feedback to improve future designs.

The mission aimed to push the limits of private companies in space, with ground teams at SpaceX’s California headquarters monitoring the hatch’s closure and carrying out safety checks as the astronauts returned inside.

The spacewalk procedure echoed that of the first US spacewalk in 1965, which involved depressurising the capsule and tethering a spacesuited astronaut to it. NASA Administrator Bill Nelson hailed the mission as a “giant leap forward” for the commercial space industry and NASA’s goal of building a sustainable US space economy.

While Isaacman has not revealed the mission’s cost, it is expected to run into hundreds of millions, with Crew Dragon seats typically costing around $55 million each.

Gillis, who joined SpaceX as an intern in 2015, and Poteet, a retired US Air Force lieutenant colonel, were among the crew, along with SpaceX engineer Anna Menon. Throughout the mission, the spacecraft circled Earth multiple times, reaching altitudes of up to 1,400 km, the farthest humans have travelled in space since Apollo’s final mission in 1972.

Spacewalks have previously been conducted solely by government-trained astronauts. Since the International Space Station (ISS) was established in 2000, there have been around 270 spacewalks, with 16 on China’s Tiangong space station.

The Polaris crew spent two and a half years training, including mission simulations and challenging real-world experiences, to prepare for the mission, according to Poteet.

Currently, a record 19 astronauts are in orbit, including 12 aboard the ISS, after a Russian Soyuz mission transported additional astronauts there on Wednesday. Since 2001, Crew Dragon has completed more than a dozen astronaut missions, primarily for NASA.

The capsule was developed under a NASA programme to create commercial vehicles for transporting astronauts to and from the ISS. Boeing’s Starliner capsule, also part of this programme, launched its first astronauts to the ISS in June but faced difficulties. It returned empty, leaving its crew aboard the station until next year, when a Crew Dragon capsule will retrieve them.

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PS5 Disc Drive is selling out after PS5 Pro announcement | The Express Tribune

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The demand for the PS5 Disc Drive has skyrocketed since the announcement of the PS5 Pro, with online retailers quickly selling out of the popular peripheral.

Gamers eager to ensure they can still play physical media on their next-gen consoles are rushing to purchase the external disc drive required for the new PS5 Pro.

Sony officially revealed the PS5 Pro earlier this week, and with it came the announcement that the console would not include a built-in disc drive.

Instead, players who want to use physical discs will need to buy the external PS5 Disc Drive, a shift that has already sparked a buying frenzy.

At the time of writing, the PS5 Disc Drive has climbed to #16 on Amazon’s best-selling video game products.

Best Buy, one of the major online retailers, has already sold out of the drive, and it is currently unavailable for order. Gamers are still able to find it on other major sites like Target, Walmart, and PlayStation Direct, but these supplies are expected to diminish quickly as well.

This rush to secure the PS5 Disc Drive began when Sony introduced the PS5 Slim in late 2023, which also required an external drive for physical game compatibility. Unlike the original PS5, which featured both disc and digital editions, the Slim removed the option of having a built-in disc drive.

 

 

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US wireless data usage surges to record 100 trillion MB in 2023 | The Express Tribune

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Americans consumed more than 100 trillion megabytes of wireless data in 2023, a 36% rise from the previous year and the largest single-year increase, according to a report from wireless industry association CTIA.

The surge in usage—an increase of 26 trillion MB over 2022—is attributed to the growing adoption of 5G devices and fixed wireless access (FWA) broadband services.

The total number of wireless connections in the US rose to 558 million, representing a 6% growth over 2022. Notably, 40% of wireless connections were 5G-enabled, covering over 330 million US residents.

Additionally, nearly 40% of all wireless devices were connected to 5G, a 34% increase from 2022.

CTIA highlighted that the sector attracted $30 billion in investment in 2023, with total spending on spectrum auctions surpassing $233 billion.

However, the association emphasized the need for Congress to restore the Federal Communications Commission’s (FCC) auction authority to ensure access to mid-band spectrum and meet the growing demand for wireless services.

By the end of 2023, the US had 432,469 active cell sites, a 24% increase since 2018, thanks to siting reforms.

The cost per megabyte of wireless data has dropped by 50% since 2020.

CTIA’s annual survey has tracked the US wireless sector since 1985.

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Black Sun Productions to launch VR game inspired by Kafka’s Metamorphosis | The Express Tribune

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Black Sun Productions, a virtual reality studio, has announced its debut title, Metamorphosis VR, will launch on October 10, 2024.

The narrative inspired by Franz Kafka’s The Metamorphosis will be available for Meta Quest 2 and 3.

This VR game offers a unique and immersive experience, allowing players to step into the surreal world of Kafka’s renowned novella.

Metamorphosis VR is a bold reimagining of the 2020 PC game Metamorphosis, originally developed by Ovid Works and Untold Tales.

The story takes place in early 1900s Vienna, following Gregor Samsa, a traveling salesman who undergoes a shocking transformation into a cockroach.

After a night out, Gregor awakens to discover his metamorphosis and embarks on a strange journey to find a way to return to his human form and save his closest friend.

“We chose Metamorphosis as our debut title for Black Sun because its surreal, Kafkaesque world – some of the richest and most immersive environments imagined – offers a perfect opportunity to bring this extraordinary experience to virtual reality,” said Corbin Chase, CEO of Black Sun Productions, in a statement, as reported by VentureBeat.

“One of VR’s most powerful abilities is how it changes our perspective and sense of scale, and Metamorphosis uniquely combines confusion, bewilderment, wonder and beauty. All imparted by that shift in perspective, it feels like this game was always meant for VR.”

One of the game’s key highlights is its distinct shift in perspective, which allows players to experience Gregor’s new reality as an insect.

Navigating through walls, floorboards, and tight spaces, the player is immersed in a bizarre world filled with bug philosophers, insect crime bosses, and creepy thespians.

The game features over 100 insect characters, each with a unique voice, contributing to an interactive experience.

Fans of Kafka’s original novella and virtual reality enthusiasts eager to explore its surreal world are anticipating the game’s October 10 release on Meta Quest 2 and 3.

 

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